Ukukhipha isisu kuyisinqumo somuntu siqu nesiyinkimbinkimbi abesifazane abaningi abangase babhekane naso esikhathini esithile ekuphileni kwabo. Eminyakeni yamuva nje, ukukhipha isisu ngokwezokwelapha kusetshenziswa amaphilisi e-Mifepristone kanye ne-Misoprostol sekuyindlela ephephile nephumelelayo yokuqeda ukukhulelwa kusenesikhathi. Lo mhlahlandlela ophelele uhlose ukunikeza ukuqonda okuningiliziwe kwalawa maphilisi, okuhlanganisa indlela asebenza ngayo, umthamo, imiphumela engemihle engaba khona, izinyathelo zokuphepha, nokunakekelwa kokulandelela.
I-Mifepristone ne-Misoprostol yimithi esetshenziswa ngokuhlangene ukuze kukhishwe isisu sezokwelapha. I-Mifepristone, eyaziwa nangokuthi iphilisi lokukhipha isisu noma i-RU-486, iyisidakamizwa esilwa ne-progesterone esivimba i-hormone edingekayo ukuze kugcinwe ukukhulelwa. I-Misoprostol, i-analogue ye-prostaglandin, isetshenziselwa ukubangela ukufinyela kwesibeletho, okuholela ekuxoshweni kokukhulelwa. Ref
I-Mifepristone isebenza ngokuvimbela ama-progesterone receptors esibelethweni, okwenza ulwelwesi luqhekeke futhi luvimbele ukukhulelwa ukuthi kuqhubeke. Ngemva kokuthatha i-Mifepristone, i-Misoprostol ivame ukunikezwa phakathi kwamahora angu-24 kuya kwangu-48 ukuze ibangele ukufinyela nokuxosha ukukhulelwa. Inhlanganisela yale mithi emibili iphumelela kakhulu, namazinga empumelelo acishe abe ngu-95-98% wokukhulelwa kuze kufike emavikini angama-20 okukhulelwa.
Umthamo ojwayelekile we-Mifepristone ngu-200mg, othathwa ngomlomo ngaphansi kokuqondisa kwezokwelapha. Ngemva kwamahora angu-24 kuya kwangu-48, amaphilisi amane e-Misoprostol angu-200mcg afakwa ngaphansi kolimi noma afakwe esithweni sangasese. Amaphilisi e-Misoprostol angayiswa ekhaya, futhi kunconywa ukuthi alale imizuzu engu-30 ngemva kokuphathwa. Kubalulekile ukulandela umthamo onqunyiwe kanye nemiyalo ehlinzekwa uchwepheshe wezempilo.
Njenganoma yimuphi umuthi, i-Mifepristone ne-Misoprostol ingabangela imiphumela emibi. Imiphumela emibi evamile ye-Mifepristone ihlanganisa isicanucanu, ukuhlanza, isifo sohudo, nobuhlungu besisu. I-Misoprostol ingase ibangele ukuminyanisa, ukopha kakhulu, isicanucanu, nomkhuhlane. Le miphumela engemihle ivamise ukuba mnene futhi eyesikhashana, ihlala amahora ambalwa kuya ezinsukwini ezimbalwa. Kodwa-ke, uma imiphumela emibi enzima noma ende yenzeka, ukunakekelwa kwezokwelapha kufanele kufunwe ngokushesha.
Ngaphambi kokukhetha ukukhipha isisu ngokwezokwelapha, kubalulekile ukuthintana nomhlinzeki wezempilo ukuze uqinisekise ukuthi kuphephile futhi kufanelekile esimweni sakho esithile. I-Mifepristone ne-Misoprostol ngokuvamile ziphephile, kodwa zingase zingafaneleki kwabesifazane abanezimo ezithile zezokwelapha noma labo abangaphezu kweminyaka ethile yokukhulelwa. Kubalulekile futhi ukufinyelela ekunakekelweni kwezokwelapha okuphuthumayo uma kwenzeka kuvela izinkinga phakathi nenqubo.
Ngemva kokuhushula isisu ngokwezokwelapha, kubalulekile ukuba nokunakekelwa kokulandelela ukuze uqinisekise ukuthi ukukhipha isisu kuphelile futhi ubhekane nanoma yikuphi ukukhathazeka noma izinkinga. Umhlinzeki wezempilo uzohlela isikhathi sokulandelela ukuze aqinisekise impumelelo yokuhushula isisu futhi anikeze noma yikuphi ukunakekelwa okudingekayo ngemva kokukhipha isisu. Ukwesekwa ngokomzwelo nakho kubalulekile ngalesi sikhathi, futhi izinsizakalo zokwelulekwa noma amaqembu okusekela angaba yinzuzo kulabo abadinga usizo olwengeziwe.
Amaphilisi e-Mifepristone kanye ne-Misoprostol anikeza enye indlela ephephile nephumelelayo yokuhushula isisu ngokuhlinzwa kwabesifazane abaningi. Kodwa-ke, kubalulekile ukukhumbula ukuthi ulwazi lwawo wonke
I-Mifepristone ne-Misoprostol yimithi esetshenziswa ngokuhlangene ukuze kukhishwe isisu sezokwelapha. I-Mifepristone, eyaziwa nangokuthi iphilisi lokukhipha isisu noma i-RU-486, iyisidakamizwa esilwa ne-progesterone esivimba i-hormone edingekayo ukuze kugcinwe ukukhulelwa. I-Misoprostol, i-analogue ye-prostaglandin, isetshenziselwa ukubangela ukufinyela kwesibeletho, okuholela ekuxoshweni kokukhulelwa.
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